Anwesha Chatterjee

• PhD, Pharmacology-Toxicology, (University of Missouri, Kansas City, MO, USA)
• Masters of Science, Cell and Molecular Biology, (University of Missouri, Kansas City, MO, USA)
• Masters of Science, Biotechnology, )University of Utkal, Bhubaneswar, India)

• Molecular Oncology: Breast Cancer
• Metal-induced lung carcinogenesis
• Role of exosomes in onset & progression of cancer
• Novel drug development strategies in breast & lung cancer
• Cancer stem cells

• Thomas D. Ross Graduate Pharmacology Scholarship Award, UMKC, 2010.
• Robert C. Lanman Graduate Pharmacology Scholarship Award, UMKC, 2012.
• “Best Poster” Award, Division of Pharmacology & Toxicology, UMKC, 2012.
• UMKC Women’s Council Graduate Assistance Fund (GAF) Award, UMKC, 2013.
• Division’s/Dean’s Travel Award, Division of Pharmacology & Toxicology, School of Pharmacy, UMKC, 2013 & 2014.
• Interdisciplinary Doctoral Student Council (IDSC) Travel Grant Award for Conference Presentation, UMKC, 2013 & 2014
• Richard and Paula Johnson Pharmacy Graduate Student Award, 2013.
• UMKC Women’s Council Graduate Assistance Fund (GAF) Merit Award, UMKC, 2014.
• UMKC School of Graduate Studies Research grant, 2014

Research interest/Experience:

• Worked on molecular biology of Cancer (Effects of environmental toxins such as heavy metals and toxic effects of estrogen hormone in the onset and progression of cancer) and Chemoprevention (Breast cancer and Lung cancer) for last seven+ years (2009-present). I have also worked in drug development against breast cancer.

• I have worked in the area of molecular biology and chemoprevention of breast cancer as a graduate student. I have also worked in drug development against breast cancer including use of natural cancer therapeutics in xenograft rodent models. I have utilized my knowledge and skills in pharmacology and molecular biology for cancer research. I have completed my Post-Doctoral work from University of Kentucky, Lexington. My Post-doctoral research was focused on molecular mechanism of metal-carcinogenesis. My work also includes developing strategies for inhibition of arsenic-induced lung cancer in vitro & in vivo systems.
• I have skills in pharmacology and molecular biological techniques. Currently I worked as a Post-Doc Scientist at University of Kentucky, Lexington on Arsenic-induced lung-carcinogenesis. I have a solid background in biochemistry/molecular Biology; I have experience in cancer molecular biology & Pharmacology-Toxicology research including use of natural cancer therapeutics in xenograft rodent models and xenograft tumor characterization. My work also includes developing strategies for inhibition of environment-induced breast cancer by natural antioxidants and novel drug analogs. In future, I also have plans to develop exosome-mediated drug delivery system which has the potential of successful drug delivery as well as reducing toxicity associated with existing chemotherapy. I have worked with exosome in my Post Doctoral training period. This field is not much explored in India and worldwide and so it has potential innovativeness.

Work Experience:
Present work status-
Assistant Professor of Biotechnology, ADAMAS University, Kolkata, WB, India (Oct 2018-Present)

Sciegen Pharmaceuticals, NY; July 2016-June 2017

• Research Scientist
• Development and analysis of drug products

University of Kentucky, Lexington, KY 2014–2016

• Post-Doctoral Scientist

Department of Toxicology & Cancer Biology. Research project on molecular mechanism and chemoprevention of Arsenic-induced lung carcinogenesis (Specifically, Role of Exosomes in Metal-induced lung carcinogenesis).

Teaching Experience:

• Instructor for Pharm D courses including Pharmacology I & II (Introduction, Drug metabolism, Cholinergic pharmacology, Autonomic pharmacology, Local anesthetics, Anti-inflammatory drugs, Vasoactive and lipid lowering drugs, Antihistamines, Neuropharmacology, Antimicrobial drugs, Opioids, Chemotherapy etc); Toxicology (Principles of Toxicology, Mechanisms of action of different drug classes, Drugs of abuse – CNS depressants, CNS stimulants, Narcotics, Recreational drugs, NSAIDS, drug abuse in anorexia etc); Pharm Immunizations (P7334), Top 200 I (P7245), Medical Terminology (Introduction, Commercial applications of Pharmacoeconomics, different anatomical and physiological systems of human body, Patient diagnosis, Pharmacology etc); Top 200 II ( P7345), Pharmacoeconomics (Introduction to Pharmacoeconomics, Cost-Minimization, Cost -Effectiveness, Cost-benefit analysis, Preferences, Clinical Trials, Ethics, Patient level outcome analysis etc).
• Assistant Professor of Biotechnology, ADAMAS University, Kolkata, WB, India (Present)
  Teaching UG/PG courses: Biochemistry, Genetics, Mammalian Physiology, Zoology, Cancer Biology, Stem cell biology, Techniques in Biotechnology, Cell & Molecular Biology, Tissue engineering and forensic biology
• Guided more than 30 students for Dissertation

In reputed Journals like: Carcinogenesis, BMC Cancer, Toxicology & Applied Pharmacology, Journal of Steroid Biochemistry & Molecular Biology, Oncotarget, Biorg.Med.Chem.Lett., Journal of Biochemical & Molecular Toxicology.

Selected Publication (s)

1. Antioxidant activities of novel resveratrol analogs in breast cancer. JBMT. 2017. Anwesha Chatterjee1, Amruta Ronghe1, Subhash B. Padhye2,David A. Spade3, Nimee K. Bhat1 and Hari K. Bhat1
2. Chatterjee, A., Singh, B., Ronghe, A., Bhat, N K. Chen, J. and Bhat, H K. (2014). Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC-bZip transcription factors in Estrogen induced breast carcinogenesis. Journal of Biochemical & Molecular Toxicology (PMID: 25130429).
3. Ronghe, A., Chatterjee, A., Singh, B., Dandawate, P., Murphy, L., Bhat, N. K., Padhye, S. and Bhat, H. K. (2014). Differential regulation of estrogen receptors α and β by 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol}, a novel resveratrol analog. Journal of Steroid Biochemistry & Molecular Biology (PMID 25242450).
4. Singh, B., Shoulson, R., Chatterjee, A., Ronghe, A., Bhat, N. K., Dim, Daniel C and Bhat, H. K. (2014). Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways. Carcinogenesis. 35(8): 1872-80.
5. Siddiqui, A., Dandawate, P., Rub, R., Padhye, S., Aphale, S., Moghe, A., Jagyasi, A., Swamy, K V., Singh, B., Chatterjee, A., Ronghe, A. and Bhat, H. K. (2013). Novel Aza-Resveratrol Analogs: Synthesis, Characterization and Anticancer Activity against Breast cancer cell lines. Biorg.Med.Chem.Lett. 23(3):635-40.
6. Singh, B., Ronghe, A., Chatterjee, A., Bhat, N. K. and Bhat, H. K. (2013). MicroRNA-93 regulates NRF2 expression and is associated with breast carcinogenesis. Carcinogenesis. 34(5):1165-72.
7. Singh, B., Chatterjee, A., Ronghe, A., Bhat, N. K. and Bhat, H. K. (2013). Antioxidants-mediated up regulation of OGG1 via NRF2 induction is associated with prevention of oxidative DNA damage in estrogen-induced breast cancer. BMC Cancer. 13:253-261.
8. Amruta Ronghe, Anwesha Chatterjee, Bhupendra Singh, Prasad Dandawate, Fatma Abdalla, Nimee K. Bhat, Subhash Padhye, Hari K. Bhat 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, 1 a novel resveratrol analog, differentially regulates estrogen receptors α and β in breast cancer cells Toxicology and Applied Pharmacology Volume 301, 15 June 2016, Pages 1–13
9. Amruta Ronghe, Anwesha Chatterjee, Nimee K. Bhat, Subhash Padhye, Hari K.
   Bhat Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells Oncotarget, Vol. 7, No. 32.
   
10. Anwesha Chatterjee, Amruta M. Ronghe Subhash B. Padhye, Nimee Bhat and Hari K. Bhat. Novel resveratrol analog HPIMBD inhibits growth of breast cancer cells with a preference towards triple negative breast cancer cells by inducing autophagy (Submitted).
11. Anwesha Chatterjee, Amruta M. Ronghe, Subhash B. Padhye, Nimee Bhat and Hari K. Bhat. Anti-metastatic effects of novel resveratrol analogs TIMBD and HPIMBD in breast cancer (Submitted).
12. Title: 4-(E)-{(4-hydroxyphenylimino)-methylbenzene,1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, differentially regulate the expressions of cytochrome P450 enzymes (1A1, 1B1) and Arylhydrocarbon receptor in breast cancer cells Corresponding Author: Dr. Hari K Bhat Co-Authors: Amruta Ronghe, PhD; Shakeel Mir, PhD; Anwesha Chatterjee, PhD; Bhupendra Singh, PhD; Prasad Dandawate, PhD; Subhash Padhye, PhD; Melissa LT Teo-Fitzgerald, PhD (Submitted)

     Abstracts:

13. Chatterjee, A., Singh, B., Ronghe, A. and Bhat, H K. “Role of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) in Estrogen-induced Breast Carcinogenesis”. UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 20th 2011.
14. Chatterjee, A., Singh, B., Ronghe, A. and Bhat, H K. “A synthetic analog of resveratrol: “ARSMA” a better drug against breast cancer”. UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 20th 2012.
15. Chatterjee, A., Ronghe, A., Singh, B., Padhye, S. and Bhat, H K. “Novel resveratrol analog ARSHA shows higher potency for inhibiting the growth of triple negative breast cancer cells.” UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 4th 2013.
16. Chatterjee, A., Ronghe, A., Singh, B., Padhye, S. and Bhat, H K. “Novel resveratrol analog ARSHA shows higher potency for inhibiting the growth of triple negative breast cancer cells.” Am. Assoc. Cancer Res. Annual Meeting, Washington, D.C, April 6th-10th 2013.
17. Chatterjee, A., Ronghe, A., Abdalla. F. and Bhat, H K. “Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC-bZip transcription factors in Estrogen induced breast carcinogenesis”. Am. Assoc. Cancer Res. Annual Meeting, San Diego, CA, April 5th-9th 2014.
18. Ronghe, A., Chatterjee, A., Singh, B. and Bhat, H K. “Role of Hydroxy steroid dehydrogenase 11 β2 (HSD 11 β2) in Estrogen-induced Breast Carcinogenesis. UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 20th 2011.
19. Ronghe, A., Chatterjee, A., Singh, B. and Bhat, H K. “Screening of resveratrol analogs to develop better drugs against breast cancer.” UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 20th 2012.
20. Ronghe, A., Chatterjee, A., Singh, B., Padhye, S. and Bhat, H K. “ARSHA, a novel analog of resveratrol inhibits proliferation of breast cancer cells by modulating expression of ERα & ERβ”. Abstract submitted and accepted for Am. Assoc. Cancer Res. Annual Meeting, Washington, D.C, April 6th-10th 2013.
21. Singh, B., Ronghe, A., Chatterjee, A. and Bhat, H K. “Resveratrol inhibits oxidative stress and prevents estrogen-induced breast carcinogenesis via activation of NRF2-mediated protective pathways. UMKC School of Pharmacy Health Sciences Research Summit, Kansas City, Missouri, April 4th 2013.
22. Singh, B., Ronghe, A., Chatterjee, A. and Bhat, H K. “Resveratrol inhibits oxidative stress and prevents estrogen-induced breast carcinogenesis via activation of NRF2-mediated protective pathways”. Am. Assoc. Cancer Res. Annual Meeting, Washington, D.C, April 6th-10th 2013.

• Associate Member of American Association for cancer research (2012-present), served in Graduate Program’s Committee (GPC).
• Serving as reviewer of scientific research journals: Toxicology and Applied Pharmacology (TAAP), Journal of Biochemical and Molecular Toxicology (JBT), Cogent Medicine and Biomed Research International.
• Thomas D. Ross Graduate Pharmacology Scholarship Award, UMKC, 2010.
• Robert C. Lanman Graduate Pharmacology Scholarship Award, UMKC, 2012.
• “Best Poster” Award, Division of Pharmacology & Toxicology, UMKC, 2012.
• UMKC Women’s Council Graduate Assistance Fund (GAF) Award, UMKC, 2013.
• Division’s/Dean’s Travel Award, Division of Pharmacology & Toxicology, School of Pharmacy, UMKC, 2013 & 2014.
• Interdisciplinary Doctoral Student Council (IDSC) Travel Grant Award for Conference Presentation, UMKC, 2013 & 2014
• Richard and Paula Johnson Pharmacy Graduate Student Award, 2013.
• UMKC Women’s Council Graduate Assistance Fund (GAF) Merit Award, UMKC, 2014.
• UMKC School of Graduate Studies Research grant, 2014