Dr. Subrat Kumar Bhattamisa

• PhD (Pharmacology), Banaras Hindu University, India
• Pharm (Pharmacology), Birla Institute of Technology, India
• Pharm, Berhampur University, India

• Pharmacological evaluation of natural products for their therapeutic value targeted on metabolic disorders (Type-2 diabetes mellitus, obesity, hyperlipidaemia) and CNS disorders (anxiety, depression and neurodegenerative diseases) using experimental in vivo / in vitro models and deriving the mechanism of action.

• Development of nose-to-brain delivery of rotigotine formulation for the treatment of Parkinson’s disease. This research is received grant from Ministry of Science and technology, Govt. of Malaysia.
• Single Original Research Article (Scientific) with Highest Impact Factor award in 2020 by School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
• Best Original Research Paper award in 2019 by School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
• First Prize in poster presentation in Diabetes Asia 2017 Conference, Kuala Lumpur, 12- 15 October 2017.

• Professor, Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, 2021 –
• Senior Lecturer, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia, 2014 – 2021.
• Associate Professor, Faculty of Medicine, ASIA Metropolitan University, Johor Bahru, Malaysia, 2012 – 2014.
• Professor, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India, 2009 – 2012.
• Scientist-1 and Manager, Torrent Research Centre, Ahmedabad, Gujarat, India, 2007 – 2009.
• Senior Research Fellow (UGC, New Delhi), Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India, 2004 – 2006.
• Lecturer, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India, 2001 – 2004.

• Number of research papers published in International refereed journals: 65
• Number of research papers published in International peer-reviewed Scopus Proceedings: 07
• Number of invited Book-Chapters: 01

For Details, Visit: https://adamasuniversity.irins.org/profile/229425

Selected Publication (s):

1. Bhattamisra SK, Koh HM, Lim SY, Choudhury H, Pandey M. Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications. Biomolecules. 2021; 11(2):323. (IF= 4.879; Q1).
2. Wong YL, Pandey M, Choudhury H, Lim WM, Bhattamisra SK, Gorain B. Development of In-Situ Spray for Local Delivery of Antibacterial Drug for Hidradenitis Suppurativa: Investigation of Alternative Formulation. Polymers. 2021; 13(16):2770. https://doi.org/10.3390/polym13162770 (IF= 4.329; Q1).
3. Bapat RA, Pandurangappa R, Bhattamisra SK, Heng YK, Matinlinna JP, Daood U. New Perspective for Probe Development Assessing Salivary Biomarkers in Periodontal Affected Diabetic Patients. Microchemical Journal. 2021, 106727. (IF= 4.821; Q2).
4. Pandey M, Choudhury H, Segar Singh SK, Chetty Annan N, Bhattamisra SK, Gorain B, Mohd Amin MCI. Budesonide-Loaded Pectin/Polyacrylamide Hydrogel for Sustained Delivery: Fabrication, Characterization and In Vitro Release Kinetics. Molecules 2021, 26(9):2704. (IF= 4.411; Q1).
5. Yap KH, Yee GS, Candasamy M, Tan SC, Md S, Majeed ABA, Bhattamisra SK. Catalpol ameliorates insulin sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation. Biomolecules. 2020; 10(10): 1360 (IF= 4.879; Q1).
6. Bhattamisra SK, Yap KH, Rao V, Choudhury H. Multiple Biological Effects of an IridoidGlucoside, Catalpol, and Its Underlying Molecular Mechanisms. Biomolecules. 2020;10(1):32. (IF= 4.879; Q1).
7. Bhattamisra SK, Shak AT, Xi LW, Safian NH, Choudhury H, Lim WM, Shahzad N, Alhakamy NA, Anwer MK, Radhakrishnan AK, Md S. Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson’s disease. International Journal of Pharmaceutics. 2020; 579:119148. (IF= 5.875; Q1).
8. Bhattamisra SK, Shin LY, Saad HI, Rao V, Candasamy M, Pandey M, Choudhury H. Interlink between insulin resistance and neurodegeneration with an update on current therapeutic approaches. CNS & Neurological Disorders Drug Targets. 2020; 19(3) 174-183. (IF= 4.388; Q2).
9. Elhassan SA, Candasamy M, Tan SW, Yap KH, Bhattamisra SK. Effect of madecassoside and catalpol in amelioration of insulin sensitivity in pancreatic (INS-1E) β cell line. Natural Product Research, 2019 (IF=2.861; Q2). (doi: https://doi.org/10.1080/14786419.2019.1696794).
10. Panda BP, Krishnamoorthy R, Bhattamisra SK, Shivashekaregowda NKH, Seng LB, Patnaik S. Fabrication of second generation smarter PLGA based nanocrystal carriers for improvement of drug delivery and therapeutic efficacy of gliclazide in type-2 diabetes rat model. Scientific Reports, 2019; 9:17331 (IF= 4.379; Q1).
11. Furman BL, Candasamy M, Bhattamisra SK, Veettil SK. Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies. Journal of Ethnopharmacology, 2019; 112264 (IF= 4.36; Q1).
12. Choudhury H, Zakaria NF, Tilang PA, Tzeyung AS, Pandey M, Chatterjee B, Alhakamy NA, Bhattamishra SK, Kesharwani P, Gorain B, Md S. Formulation development and evaluation of rotigotine mucoadhesive nanoemulsion for intranasal delivery. Journal of Drug Delivery Science and Technology, 2019; 101301 (IF= 3.981; Q2).

1. Project Topic: Anti-invasive role of ‘geraniol’, an acyclic monoterpene, against Helicobacter pylori using in vitro and in vivo experimental models. (FRGS; Project no.: FRGS/1/2019/SKK13/IMU/02/1; Ministry of Higher Education, Malaysia; Fund: RM 104200 (≈ 18.50 Lakhs INR); Role: Co-Researcher).
2. Project topic: Antidiabetic activity of catalpol on high-fat diet/streptozotocin-induced type-2 diabetes mice by improving insulin sensitivity and mitochondrial function (FRGS; Project no.: FRGS/1/2015/SKK10/IMU/02/1; Ministry of Higher Education, Malaysia; Fund: RM 99200 (≈ 17.50 Lakhs INR); Role: Principal Investigator).
3. Project title: Nanoformulation of rotigotine intended for direct nose to brain targeting in Parkinson disease. (eScience Project no. 02-02-09-SF0055; Ministry of Sciences and Technology, Malaysia; Fund: RM 185000; (≈ 32.70 Lakhs INR); Role: Principal Investigator).
4. Project title: Effect of madecassoside in reducing oxidative stress and blood glucose and in protecting the β-cells in streptozotocin-nicotinamide induced diabetes in rats. (FRGS; Project no. FRGS Ph2/2014 (IMU R 152/2014; Ministry of Higher Education, Malaysia; Fund: RM 135000; (≈ 24.00 Lakhs INR); Role: Co-Researcher).
5. Project title: Design and Development of second generation smarter nanocrystals for delivery of gliclazide. (Taylor’s Research Grant Scheme; Project code: TRGS/MFS/2/2016/SOP/004 Fund: RM 53400; (≈ 9.50 Lakhs INR); Role: Co-Researcher).

1. Laxmikant Chhipa, Shitalkumar Pukharaj Zambad, Ramesh Gupta, Davinder Tuli, Ashok Kasundra, Siralee Munshi, M Amir Siddiqui, Subrat Kumar Bhattamisra, C Dutt, Vijay Chauthaiwale: Pyrazole-based thyroid receptor compounds. Torrent Pharmaceuticals. Patent Grant number: US8378118 (Publication date: 19/02/2013).
2. Laxmikant Chhipa, Shitalkumar Pukharaj Zambad, Ramesh Gupta, Davinder Tuli, Ashok Kasundra, Siralee Munshi, M Amir Siddiqui, Subrat Kumar Bhattamisra, Chaitanya Dutt, Vijay Chauthaiwale: Thyroid like compounds.Torrent Pharmaceuticals. Patent Grant number: US8143424 (Publication date: 27/03/2012).
3. Laxmikant Chhipa, Shitalkumar Pukharaj Zambad, Ramesh Gupta, Davinder Tuli, Ashok Kasundra, Siralee Munshi, M Amir Siddiqui, Subrat Kumar Bhattamisra, C Dutt, Vijay Chauthaiwale: Novel compounds. Torrent Pharmaceuticals. Patent application number: US20120202816; US2010168110; CA2698704;WO2008149379; EP2061766; AU2008259314; MX2009013070; HK1129221; NZ582273; RS51501; ES2351274T; DK2061766T; SI2061766T; PT2061766T; AT478053T; KR20100022104.

• Doctoral Thesis Advisor / Supervisor : 5 (3 Awarded, 2 Submitted)
• Post Graduate Thesis Advisor / Supervisor: 15 (Awarded)

• Editor, European Journal of Clinical and Biomedical Sciences
• Editor, Research Journal of Pharmacy and Life Sciences
• Reviewer, Journal of ethnopharmacology, Healthcare, Pharmaceutical Biology, Pharmacognosy magazine, FEBS journal and many other international journals
• Fellow, Institute of Chemist, India
• Life member, Association of Pharmaceutical Teachers of India (APTI), India.
• Life member, Indian Pharmaceutical Association (IPA), India.
• Life member, Indian Pharmacological Society (IPS), India.