About the 2nd Subhash Mukhopadhyay Symposium

Human germline is a new research frontier and except for the gene regulatory network that governs the specification of this lineage at around 3rd week of gestation, nothing much is known about it especially because the ethical constraints and technical challenges associated to the access of the human primordial germ cells that undergoes most extra-ordinary epigenetic reprogramming which is characterized by acutely hypomethylated whereby DNA methylation is virtually wiped out, besides loss of other epigenetic constraints. Such establishment of epigenetic ground state is not only critical for human germ cells to initiate meiosis and gametogenesis but also for the establishment of totipotency and subsequent development to term. On the other hand, the genes encompassing a handful of loci that exhibits resistance to this onslaught of global epigenetic resetting serves as the only candidates of transgenerational/intergenerational epigenetic inheritance in human. While in-vitro gametogenesis has been possible in case of rodents, our understanding about meiotic entry and formation of gametes in primates remains obscure as all the efforts to recreate gametes from in-vitro-derived primordial germ cells of primates, including that of human, have failed thus far. In addition, epigenetic inheritance has major implications on health and diseases as it enables transmission of genes associated to various neurological and metabolic disorders in a repressed state, however the mechanism of inheritance of epigenetic state in mammals remains elusive. Thus, the objective of this event is to provide exposures to the ground-breaking work of leading scientists across the world in the field of meiosis and epigenetic inheritance, thereby creating a platform to interact with them which might create avenues for potential collaboration. This symposium will thus provide a unique opportunity to discuss how recent advances in the field of mammalian germline have re-invigorated the field that led to paradigm shift in our concepts about various facets of early embryonic development and what obstacles we may encounter in unravelling how epigenetic regulation orchestrates fundamental biological processes during the early phase of development in human.

Registration Deadline

20th of December 2022

Speakers

Ramiro Alberio

University of Nottingham; UK

Ben Black

University of Pennsylvania; USA

Elvan Böke

Centre for Genomic Regulation;
Spain

Maud Borensztein

CNRS-Institute of Molecular
Genetics of Montpellier; France

Sylvia Erhardt

Karlsruhe Institute of Technology;
Germany

Hiyaa Ghosh

National Centre for Biological
Sciences; India

Arjun Guha

Institute for Stem Cell Science and Regenerative Medicine; India

Edouard Hannezo

Institute of Science and
Technology Austria; Austria

Azusa Inoue

Riken Centre; Japan

Nicola Iovino

Max Planck Institute of Immunobiology and Epigenetics; Germany

Michael Lampson

University of Pennsylvania; USA

Nibedita Lenka

National Centre for Cell
Science; India

Arindam Maitra

National Institute of
Biomedical Genomics; India

Harmit Malik

Fred Hutchinson Cancer
Research Center; US

Sudip Mandal

Indian Institute of Science
Education and Research –
Mohali; India

Phillip Newmark

University of Wisconsin-
Madison/Morgridge Institute
for Research; USA

Renee Reijo Pera

McLaughlin Research Institute
for Biomedical Sciences;
USA

Nicolas Plachta

University of Pennsylvania;
USA

Shravanti Rampalli

CSIR – Institute of Genomics
and Integrative Biology; India

Oliver Rando

University of Massachusetts;
USA

Kotaro Sasaki

University of Pennsylvania; USA

Upasna Sharma

University of California – Santa Cruz; USA

Mijo Simunovic

Columbia University; USA

Susan Strome

University of California –
Santa Cruz; USA

Sudhir Thakurela

Harvard University; USA

Jan Zylicz

University of Copenhagen; Denmark

Programme (Time mentioned is as per Indian Standard Time)

15:30-15:45 Introduction
Session 1:
Chair:
Nishant Singhal, National Centre for Cell Science, India
15:45-16:30 Genomic imprinting mediated by maternal histone modifications
Azusa Inoue
16:30-17:15 Mechanisms by which oocytes evade ageing: oocytes have ROS-free mitochondria
Elvan Böke
17:15-18:00 X-chromosome dynamics during female development
Maud Borensztein
18:00-18:45 Epigenetics of early development
Nicola Iovino
18:45-19:00 Break
Session 2:
Chair:
Maharshi Krishna Deb, Subhash Mukhopadhyay Centre for
Stem Cell Biology and Regenerative Medicine, Adamas
University, India
19:00-19:45 Genetic and epigenetic facets driving centromere function and evolution
Ben Black
19:45-20:30 Imaging how the early mammalian embryo forms
Nicolas Plachta
20:30-21:15 Lingering memories: effects of paternal exposures on health and disease in offspring
Oliver Rando
21:15-22:15 Transcriptional Control of Human Male Germ Cell Development 
Renee Reijo Pera (Keynote)
22:15-23:00 Sperm RNA-mediated intergenerational epigenetic inheritance
Upasna Sharma
Session 3:
Chair:
Maneesha Inamdar, Institute for Stem Cell Science and Regenerative Medicine, India
15:45-16:30 Chromatin as a sensor of metabolic change in early mammalian development.
Jan Zylicz
16:30-17:15 Locus-specific chromatin profiling reveals a direct effect of BET inhibitors at centromeres
Sylvia Erhardt
17:15-18:00 Topology of the early embryo
Edouard Hannezo
18:00-18:45 Germline development in non-rodent mammals
Ramiro Alberio
18:45-19:00 Break
Session 4:
Chair:
Srimonta Gayen, Indian Institute of Science, India
19:00-19:45 Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells
Kotaro Sasaki
19:45-20:30 Modeling human post-implantation embryogenesis in vitro
Mijo Simunovic
20:30-21:15 Violation of Mendel’s First Law: meiotic drive and evolutionary innovation in centromere proteins
Michael Lampson
21:15-22:00 Delays in Transcription Factor Decommissioning Facilitate Pluripotency Reacquisition 
Sudhir Thakurela
22:00-23:00 Inherited Chromatin States Shape Transcription Patterns in Offspring and Grandoffspring
Susan Strome (Keynote)
Session 5:
Chair:
Maharshi Krishna Deb, Subhash Mukhopadhyay Centre for Stem Cell Biology and Regenerative Medicine, Adamas University, India
09:30-10:30 Evolution-guided dissection and enhancement of antiviral proteins
Harmit Malik (Keynote)
10:30-11:15 A non-ribosomal peptide triggers sexual development in planarians
Phillip A. Newmark
11:15-11:30 Break
11:30-12:15 USP and differential cell-fate modulation from embryonic stem cells 
Nibedita Lenka
12:15-13.00 Longitudinal DNA methylation profile of peripheral blood in women during pregnancy informs birth outcome
Arindam Maitra
13:30-14.00 Lunch
Session 6:
Chair:
Srimonta Gayen, Indian Institute of Science, India
14.00-14.45 Metabolic regulation of cardiac ECM remodeling in Drosophila in health and disease
Sudip Mandal
14.45-15.30 Beyond stem cells and regeneration: latent adaptive properties of the adult brain cells 
Hiyaa Ghosh
15.30-15.45 Break
15:45-16.30 Regulation of cellular plasticity in the lung during homeostasis and injury-repair
Arjun Guha
16:30-17:15 Emergence of Variant Human ES cells in culture: Insights from multifaceted roles of lysine methyltransferases
Shravanti Rampalli
17:15-17:30 Vote of thanks

Registration

Registration Deadline

20th of December 2022

Registration includes:

  • Full access including abstract, kits, and other accessories
  • Food, snacks, and beverages

Excluding accommodation

Payment

  • All selected participants will be sent an email link to process payment.
  • Payment will be made through a gateway provided by the bank chosen by us.
  • The payment has to be made within a stipulated time, failing to do so, the candidate will lose the opportunity to participate and a chance will be given to the next in the waitlist.
  • After payment, the participant has to enter the transaction ID on a separate Google Sheet provided by us, which will be used to match the details.

Selection criteria

  • CV
  • Motivation letter stating your reason for interest in human germline research, and how the symposium would advance your current or future research
  • For students (reference letter from the PI/mentor)

 

Contacts

Srimonta Gayen

srimonta@iisc.ac.in                     

Organizers

Maharshi Krishna Deb

Subhash Mukhopadhyay Centre
for Stem Cell Biology and
Regenerative Medicine, Adamas
University, India

Srimonta Gayen

Indian Institute of Science, India

Venue

Rabindranath Tagore Auditorium, Adamas University

Adamas Knowledge City, Barasat – Barrackpore Road, North 24 Parganas, Kolkata – 700 126,
West Bengal, India

 

Transport

Reaching Adamas University, Kolkata, West Bengal India

By plane

All international/domestic planes coming to Kolkata land at Netaji Subhash Chandra Bose International Airport (CCU). The venue is about 16 km from the airport and can be reached via cabs or by public transport.

Via cab

Cabs can be found right outside the international/domestic terminals which can be hired to the venue.

Via public transport

Outside the airport there is designated place where AC buses can be found at regular intervals which ferry passengers to various parts of the city. To reach the venue, one has to take the AC55 bus and get down at Adamas University stop, or can take any other public buses coming towards Barasat, get down at Colony More bus stoppage and take an auto/toto to Adamas University.

 

By train

There are two major railway stations in/near Kolkata: Sealdah Station (28 Km) and Howrah station (32.5 Km). The venue can be reached from both the stations via cab or public transport.

Via cab

Cabs can be found right outside the railway stations which can be hired to the venue.

Via public transport                                                                                                                       

There are multiple ways of reaching the venue from the railway stations. From Sealdah Station, two options are there: one has to take a train to Barasat Junction Station and then take an auto/ toto to Adamas University; or take a train to Barrackpore Station and then take a bus to Adamas University. From Howrah Station, take L238 bus/ any other public buses coming towards Barasat, get down at Colony More bus stoppage and take an auto/ toto to Adamas University.